Effect of external washing with self-made Xiaofeng Jiedu powder on expressions of serum inflammatory cytokines in patients with cutaneous adverse events induced by programmed cell death protein 1 inhibitor

Wide application of programmed cell death protein 1 (PD-1) inhibitor for tumor treatment has led to increased immune-related adverse events (irAEs), particularly cutaneous irAE. In this study, we assessed the effects external washing with self-made Xiaofeng Jiedu powder on expressions serum inflammatory cytokines in patients (AEs) induced by PD-1 inhibitor. Fifty-six AEs were randomly divided into observation and control groups (n=28). The group underwent routine oral administration cetirizine, while received soaking fumigation affected skin once morning evening. levels interleukin-6 (IL-6), IL-10, immunoglobulin E (IgE) detected before after treatment. After treatment, disease rate was higher than that (P <0.05), also had objective response [71.4% (20/28) vs. 28.6% (8/28), P <0.05]. IL-6 IgE lower those thecontrol group, whereas level IL-10 former significantly <0.05). exerts evident therapeutic inhibitor-induced AEs.